SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nuclear envelope
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text
| growth cones of developing neurites |
basic FUNCTION
| regulator of JNK-signaling pathway |
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mediating the axonal transport of at least I class of vesicles by interacting directly with kinesin light chain |
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involved in the neuronal apoptosis following cerebral ischemia and hypoxia(critical component of the stress -induced JNK signaling and neuronal apoptosis) |
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cooperative scaffold for activation of JNK and regulation of cell migration in response to fibronectin (FN) stimulation |
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functions as a scaffold protein for JNK cascade molecules to efficiently activate JNKs |
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having a KIF1A-dependent adaptor function that appears to connect the KIF1A motor to KIF1A1 cargoes that are carried on or within small transport vesicles |
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may be important for the differentiation of the mesodermal lineages, functioning as a positive factor for cardiomyocyte differentiation, and as an inhibitory factor for differentiation into other lineages |
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antagonizes the mitogenic effect of SHH on cerebellar granule cell precursors and promotes their exit from the cell cycle and differentiation, by modulating JNK activity |
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crucial for the regulation of neurite morphogenesis as a downstream effector of ARF6 |
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positive regulator of kinesin activity and motility |
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role for MAPK8IP3-mediated NTRK2 anterograde axonal transport in recruiting more NTRK2 into distal axons and facilitating BDNF-induced retrograde signaling and synapse modulation |
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acts together with a GAP protein SPAG9 to promote presynaptic assembly |
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is necessary for the retrograde transport of two distinct cargos, active JNK and lysosomes |
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MAPK8IP3 promotes axon elongation in a kinesin- and JNK-dependent manner |
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MAPK8IP3 and SPAG9 are critical and functionally redundant in cytokinesis and control ARF6 localization to the midbody by forming a tripartite complex of MAPK8IP3/SPAG9, active ARF6, and kinesin-1 |
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MAPK8IP3, SPAG9 are positive regulators of kinesin-1-dependent axonal transport, which prevents neuronal degeneration |
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MAPK8IP3 regulation of kinesin-1 motility is critical for axon elongation and regeneration |
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SPAG9 and MAPK8IP3 play critical roles in kinesin-1-dependent axonal transport, which prevents brain neuronal degeneration |
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important regulator of axonal lysosome transport and maturation |
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critical role of MAPK8IP3-dependent axonal lysosome transport in regulating amyloidogenic amyloid precursor protein processing |
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part of the axonal transport machinery, which is essential for the function and maintenance of neurons |