basic FUNCTION
| Ca2+ selective channel, exhibiting Ca2+ dependent autoregulatory mechanisms including fast inactivation and slow down regulation |
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having a critical role in regulating lung inflammatory responses, via regulation of dendritic cell activation and subsequent T cell responses |
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playing an essential role in transcellular Ca2+ transport and being one of the most Ca2+-selective members of the transient receptor potential superfamily |
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constitutively internalized via a dynamin and clathrin-dependent mechanism, enters the recycling pathway (the recycling rate of TRPV5 is modulated by the intracellular Ca2+ concentration) |
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epithelial calcium channels that mediate apical calcium entry in the transcellular calcium transport pathway |
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constitutes the luminal gate for Ca(2+) entry in the distal convoluted tubule and has several putative PKA phosphorylation sites  |
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functions as a gatekeeper for transcellular Ca2+ reabsorption in the kidney  |
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could function in retinal pigment epithelium to mediate calcium influx from subretinal space and thus regulate changes in subretinal space calcium composition that accompany light/dark transitions  |
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constitutes the apical entry gate for Ca(2+) transport in renal epithelial cells  |
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plays a crucial role in epithelial calcium transport in the kidney  |
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TRPV5 and TRPV6 are crucial gates controlling cadmium and zinc levels in the human body especially under low calcium dietary conditions, when these channels are maximally upregulated  |
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facilitates Ca2+ reabsorption in the kidney and is regulated by sialidase and the hormone KL |
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facilitates transcellular Ca2+ transport in the distal convoluted tubule (DCT) of the kidney |
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is one of the two channels in the TRPV family that exhibit high selectivity to Ca(2+) ions  |
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mediates Ca(2+) influx into cells as the first step to transport Ca(2+) across epithelia  |
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possible role of TRPV5 in hypercalciuric disorders in humans  |
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active Ca(2+) reabsorption in the late distal convoluted and connecting tubules (DCT2/CNT) is initiated by Ca(2+) influx through the transient receptor potential vanilloid type 5 (TRPV5) Ca(2+) channel  |
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TRPV5 and TRPV6 play vital roles in calcium homeostasis as Ca(2+) uptake channels in epithelial tissues  |