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FLASH GENE

Symbol

BANP

contributors: mct/npt - updated : 03-12-2024

HGNC name	BTG3 associated nuclear protein
HGNC id	13450

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Lymphoid/Immune spleen       highly Reproductive female system breast         female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	putative DNA binding domain
	multimerization domain
	a BEN (BANP, E5R, and NAC1) domain binding to a CGCG DNA sequence or an AAA-containing matrix attachment regions DNA sequence

HOMOLOGY

interspecies

homolog to murine Satb1

Homologene

FAMILY	cuticular collagen family
	BANP/SMAR1 family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies

basic FUNCTION	modulaing chromatin and acting as negative regulators of the TCRbeta enhancer
	tumor suppressor protein can modulate NF-KB transactivation and inhibit tumorigenesis by regulating NF-KB target genes (Singh 2009)
	is one such nuclear matrix associated protein whose expression is drastically reduced in higher grades of breast cancer
	BANP is an important player in EP300-TP53 regulated DNA damage signalling pathway and can exert its effect on apoptosis in a transcription independent manner
	BANP is a strong CpG island (CGI) activator that controls essential metabolic genes in pluripotent stem and terminally differentiated neuronal cells
	opens chromatin and activates CpG-island-regulated genes
	negatively regulates adipogenesis
	BANP regulates transcription of metabolic genes via a CGCG-containing motif called the BANP motif
	is indispensable for the DNA damage response and chromosome segregation during mitosis
	is required for cell-cycle progression and cell survival by regulating DNA damage responses and chromosome segregation during mitosis
	can induce vascular endothelial cells (VECs) senescence by promoting TP53 phosporylation and nuclear retention
	BANP and BEND3 preferentially bind DNA bearing unmethylated CpG motifs, and they function as CpG island-binding proteins

CELLULAR PROCESS	nucleotide, replication
	nucleotide, repair
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	BTG3
	interacting with histone deacetylation complex 1, SIN3, and pocket retinoblastomas to form a multiprotein repressor complex
	may also interact with a specific nuclear matrix/scaffold-associated region (MAR)
	is sensitive to TP53 and acts as a stress inducer as well as a regulator in the TP53 regulatory network
	can also regulate apoptosis in the presence of HDAC1, depending on the stress induced by it
	TOPORS binds on the BANP promoter and its occupancy increases upon LPS treatment
	BANP acts as a repressor of signal transducer and activator of transcription 3 (STAT3) transcription
	CDC20 mediated proteasomal degradation of BANP during adipogenesis
	functions likely as a negative regulator of adipogenesis by inhibiting PPARG expression in differentiating adipocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in high grade breast cancer consequently enhancing the tumor-promoting functions of NF-KB (Singh 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS