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FLASH GENE
Symbol TTYH1 contributors: mct - updated : 05/11/2008
HGNC name tweety homolog 1 (Drosophila)
HGNC id 13476
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
a C terminal repetitive region, five putative transmembrane segments
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Ttyh1 (91.8 pc)
homolog to murine Ttyh1 (91.6 pc)
intraspecies paralog to TTYH2
Homologene
FAMILY
  • tweety family
    • CATEGORY adhesion , transcription factor , receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
    • basic FUNCTION
  • functioning as a calcium(2+)-independent, volume-sensitive large conductance chloride channel
  • may be involved in cell adhesion
  • possibly involved in regulation of cell volume
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • Cl- transport
    • PATHWAY
    metabolism metal
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cl-
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS