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FLASH GENE
Symbol TTYH1 contributors: mct - updated : 05/11/2008
HGNC name tweety homolog 1 (Drosophila)
HGNC id 13476
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly
 nerve   highly
Visualeye   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
a C terminal repetitive region, five putative transmembrane segments
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Ttyh1 (91.8 pc)
homolog to murine Ttyh1 (91.6 pc)
intraspecies paralog to TTYH2
Homologene
FAMILY
  • tweety family
    • CATEGORY adhesion , transcription factor , receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
    • basic FUNCTION
  • functioning as a calcium(2+)-independent, volume-sensitive large conductance chloride channel
  • may be involved in cell adhesion
  • possibly involved in regulation of cell volume
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • Cl- transport
    • PATHWAY
    metabolism metal
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cl-
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS