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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TTYH1

contributors: mct - updated : 05/11/2008

HGNC name	tweety homolog 1 (Drosophila)
HGNC id	13476

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 14 - 2045 48.9 450 - - variant 2 13 splicing 1999 49.6 460 - - also known as hTTYH1s lacking a segment of the coding region, leading to a frameshift, compared to variant 1

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly   nerve       highly Visual eye       moderately

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

a C terminal repetitive region, five putative transmembrane segments

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Ttyh1 (91.8 pc)
	homolog to murine Ttyh1 (91.6 pc)

intraspecies

paralog to TTYH2

Homologene

FAMILY

tweety family

CATEGORY

adhesion , transcription factor , receptor membrane , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	multi-pass membrane protein

basic FUNCTION	functioning as a calcium(2+)-independent, volume-sensitive large conductance chloride channel
	may be involved in cell adhesion
	possibly involved in regulation of cell volume

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	Cl- transport

PATHWAY

metabolism

metal

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Cl-

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS