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FLASH GENE
Symbol TTYH1 contributors: mct - updated : 05/11/2008
HGNC name tweety homolog 1 (Drosophila)
HGNC id 13476
Location 19q13.42      Physical location : 54.926.634 - 54.948.052
DNA
TYPE functioning gene
STRUCTURE 21.44 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2045 48.9 450 - -
13 splicing 1999 49.6 460 - -
  • also known as hTTYH1s
  • lacking a segment of the coding region, leading to a frameshift, compared to variant 1
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
     nerve   highly
    Visualeye   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
    		a C terminal repetitive region, five putative transmembrane segments
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Ttyh1 (91.8 pc)
    homolog to murine Ttyh1 (91.6 pc)
    intraspecies paralog to TTYH2
    Homologene
    FAMILY
  • tweety family
    • CATEGORY adhesion , transcription factor , receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
    • basic FUNCTION
  • functioning as a calcium(2+)-independent, volume-sensitive large conductance chloride channel
  • may be involved in cell adhesion
  • possibly involved in regulation of cell volume
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • Cl- transport
    • PATHWAY
    metabolism metal
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cl-
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS