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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TMEFF2

contributors: mct - updated : 20-12-2011

HGNC name	transmembrane protein with EGF-like and two follistatin-like domains 2
HGNC id	11867

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethylation in sporadic colorectal and bladder cancer and in ulcerative colitis associated colorectal carcinoma tumoral     --over   in androgen-dependent prostate cancer tumoral     --low   in brain cancers and is negatively correlated with PDGFA expression tumoral     --low   silencing by methylation in esophageal squamous cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	methylated SFRP2 and TMEFF2 detected in 94.2 p100, and 71.2 p100 of colorecal cancer (CRC), and methylation testing of fecal DNA may be a simple and promising non-invasive screening method for CRC and precancerous lesions
Therapy target	immunotherapeutic target for the treatment of prostate cancer

ANIMAL & CELL MODELS