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FLASH GENE
Symbol TMEFF2 contributors: mct - updated : 20-12-2011
HGNC name transmembrane protein with EGF-like and two follistatin-like domains 2
HGNC id 11867
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide,
  • putative extracellular domain with signal peptide,
  • two follistatin-like and EGF-like domains,followed by a transmembrane region, including two potential glycosaminoglycan attachment sites
  • a cytosolic tail G protein activating motif
  • TMEFF2 ectodomain promoting cell growth
    • HOMOLOGY
    interspecies homolog to murine Tmeff2
    Homologene
    FAMILY EGF/neurogulin family of growth factors
    CATEGORY tumor suppressor , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • type I transmembrane protein
  • localization to the membrane but also to the cytoplasm, where it appears in a punctate pattern
    • basic FUNCTION
  • potential survival factors for hippocampal and mesencephalic neurons
  • silencing of TMEFF2 by methylation increase probability of neoplastic transformation
  • androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells
  • having tumor suppressive and pro-apoptotic activity (
  • its tumor suppressor activity requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine
  • modulates SARDH activity to promote changes in cell growth and/or invasion
  • TMEFF1 and TMEFF2 could be playing similar roles in different tissues and/or developmental stages
  • can function to regulate PDGF signaling and is hypermethylated and downregulated in glioma and several other cancers, thereby suggesting an important role for this protein in the etiology of cancers
    • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text antiapoptosis for hippocampal including dopaminergic mesencephalic neurons
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activation of the STAT1 pathway likely represents the principal mediator of its tumor suppressive properties (
  • interaction of SARDH with TMEFF2
  • interacts with PDGFA through its extracellular domain
    • cell & other
    REGULATION
    Other regulated by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in sporadic colorectal and bladder cancer and in ulcerative colitis associated colorectal carcinoma
    tumoral     --over  
    in androgen-dependent prostate cancer
    tumoral     --low  
    in brain cancers and is negatively correlated with PDGFA expression
    tumoral     --low  
    silencing by methylation in esophageal squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • methylated SFRP2 and TMEFF2 detected in 94.2 p100, and 71.2 p100 of colorecal cancer (CRC), and methylation testing of fecal DNA may be a simple and promising non-invasive screening method for CRC and precancerous lesions
    • Therapy target immunotherapeutic target for the treatment of prostate cancer
    ANIMAL & CELL MODELS