basic FUNCTION
| involved in the process of elastin deposition |
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may regulate elastogenesis and vascular cell maintenance by stabilizing molecular interactions between elastic fiber components and by endowing elastic fibers with specific cell adhesion properties |
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may inhibit TGF-beta signaling by binding specifically to the proTGF-beta precursor and preventing its maturation by furin convertases in the extracellular space |
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promoting cell movement |
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activating ATR which is a crucial steph in the initiation of ATR-dependent signaling processes |
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important roles in regulating blood pressure, homeostasis, cell adhesion and cell migration |
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major stromal element determining human trophoblast invasion of the uterine wall |
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glycoprotein of elastic tissues, involved in the regulation of the growth and in the maintenance of the integrity of lymphatic vessels, a fundamental requirement for efficient function |
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local regulator of lymphangiogenesis |
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implicated in maintaining blood pressure homeostasis via the N-terminal elastin microfibril interface domain and in trophoblast invasion of the uterine wall via the globular C1q (gC1q) domain |
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negative regulator of the transforming growth factor-beta (TGF-beta) signaling, which is involved in blood pressure (BP) homeostasis |
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neutrophil elastase cleaved EMILIN1 in three/four major fragments, causing the impairment of its anti-proliferative role |
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potential involvement of EMILIN1, EMILIN2 in fibrillin-related skin disorders |
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is associated with elastin in the extracellular matrix (ECM) of arteries, lymph vasculature, and other tissues |
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EMILIN1 induces anti-tumor effects by up-regulating TSPAN9 expression in gastric cancer |
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potential role of EMILIN1 in the pathogenesis of diseases affecting the peripheral nervous system |
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EMILIN1, EMILIN2, and EMILIN3 are microfibril-associated glycoproteins known to modulate cell behaviour, growth factor activity, and ECM assembly |
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role of EMILINs in dentinogenesis, pulp biology, and inflammation |
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EMILIN1 has intrinsic tumor and metastasis suppressive-like properties reducing effective migration, cell viability, primary tumor growth, and metastasis |
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EMILIN1 connects elastic fiber network with collagen fibril formation, relevant for both bone and vascular tissue homeostasis |
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potential role in endochondral bone growth |