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FLASH GENE
Symbol FGD3 contributors: mct/npt - updated : 16-02-2009
HGNC name FYVE, RhoGEF and PH domain containing 3
HGNC id 16027
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Rho GEF (DBL) domain
  • multiple phosphoinositide-binding domains
  • a pleckstrin homology domain (PH)
  • a distinctive FYVE domain
  • a second C terminal PH domain
    • HOMOLOGY
    interspecies ortholog to murine Fgd3
    Homologene
    FAMILY
  • FGD1 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • modulate the actin cytoskeleton, being Cdc42-specific exchange factors (Huber 2008)
  • likely couple the actin cytoskeleton with the plasma membrane (Nakanishi 2008)
  • with FGD1 play different roles to regulate cellular functions but their intracellular levels are tightly controlled by the same destruction pathway through SCF(FWD1/beta-TrCP) (Hayakawa 2008)
    • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS