Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

FGD3

contributors: mct/npt - updated : 16-02-2009

HGNC name	FYVE, RhoGEF and PH domain containing 3
HGNC id	16027

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 18 - 3470 79.3 725 - Humphray (2004) variant 2 18 - 3370 79.3 725 - Humphray (2004)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Reproductive male system prostate       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Rho GEF (DBL) domain
	multiple phosphoinositide-binding domains
	a pleckstrin homology domain (PH)
	a distinctive FYVE domain
	a second C terminal PH domain

HOMOLOGY

interspecies

ortholog to murine Fgd3

Homologene

FAMILY

FGD1 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

intracellular

basic FUNCTION	modulate the actin cytoskeleton, being Cdc42-specific exchange factors (Huber 2008)
	likely couple the actin cytoskeleton with the plasma membrane (Nakanishi 2008)
	with FGD1 play different roles to regulate cellular functions but their intracellular levels are tightly controlled by the same destruction pathway through SCF(FWD1/beta-TrCP) (Hayakawa 2008)

CELLULAR PROCESS

protein

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS