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FLASH GENE
Symbol BCAT1 contributors: mct/npt/pgu - updated : 10-03-2010
HGNC name branched chain aminotransferase 1, cytosolic
HGNC id 976
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CXXC motif with thiols groups (C335 and C338 directly involved in the reversible redox regulation of BATC1)
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • class-IV pyridoxal-phosphate-dependent aminotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the transamination of the essential branched chain amino acids (leucine, isoleucine and valine) with alpha-ketoglutarate
  • may play a certain role in nasopharyngeal carcinoma development
  • having redox mediated associations with several neuronal proteins involved in G-protein cell signaling, indicating a novel role for in cellular redox control
  • BCAT1, BCAT2 are novel biomarkers for cytosolic and mitochondrial oxidative stress
  • a role in both glutamate production and glutamate release during excitation
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
    • protein
    cell & other
    REGULATION
    Other expression in the brain specifically regulated by BDNF in a time- and region-dependent fashion
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in C-Myc induced tumors such as Burkitt's lymphoma
    tumoral     --over  
    in nasopharyngeal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS