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FLASH GENE

Symbol

BCAT1

contributors: mct/npt/pgu - updated : 10-03-2010

HGNC name	branched chain aminotransferase 1, cytosolic
HGNC id	976

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005504 11 - 8282 NP_005495 - 386 - 2008 18419134

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Adult

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Adult

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	during embryogenesis, in the brain and kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

CXXC motif with thiols groups (C335 and C338 directly involved in the reversible redox regulation of BATC1)

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

class-IV pyridoxal-phosphate-dependent aminotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzes the transamination of the essential branched chain amino acids (leucine, isoleucine and valine) with alpha-ketoglutarate
	may play a certain role in nasopharyngeal carcinoma development
	having redox mediated associations with several neuronal proteins involved in G-protein cell signaling, indicating a novel role for in cellular redox control
	BCAT1, BCAT2 are novel biomarkers for cytosolic and mitochondrial oxidative stress
	a role in both glutamate production and glutamate release during excitation

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	pyridoxal phosphate

protein

cell & other

REGULATION

Other

expression in the brain specifically regulated by BDNF in a time- and region-dependent fashion

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in C-Myc induced tumors such as Burkitt's lymphoma tumoral     --over   in nasopharyngeal carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS