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FLASH GENE

Symbol

CCT8

contributors: mct/npt - updated : 25-03-2008

HGNC name	chaperonin containing TCP1, subunit 8 (theta)
HGNC id	1623

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.36 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006585 15 - 1895 NP_006576 - 548 - Kim (2006)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   pharynx       highly Endocrine thyroid       highly Lymphoid/Immune thymus       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	TCP-1 chaperonin family
	TF50-TCP-1 family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in the folding of tubulin, actin and in neurogenesis
	decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
	required for maturation of sphingosine kinase 1 (Zebol 2009)
	CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)

CELLULAR PROCESS

protein

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS