Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCT8 contributors: mct/npt - updated : 25-03-2008
HGNC name chaperonin containing TCP1, subunit 8 (theta)
HGNC id 1623
Location 21q21.3      Physical location : 30.428.649 - 30.446.010
Synonym name
  • T-complex protein 1, theta subunit
  • chaperonin-containing t-complex polypeptide 1, subunit 8
  • chromosome 21 open reading frame 112
  • renal carcinoma antigen NY-REN-15
    • Synonym symbol(s) CCTQ, KIAA0002, D21S246, C21orf112, PRED71
    DNA
    TYPE functioning gene
    STRUCTURE 17.36 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 1895 - 548 - Kim (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     pharynx   highly
    Endocrinethyroid   highly
    Lymphoid/Immunethymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • TF50-TCP-1 family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the folding of tubulin, actin and in neurogenesis
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
    • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS