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FLASH GENE

Symbol

DMRT3

contributors: mct/npt - updated : 30-03-2018

HGNC name	doublesex and mab-3 related transcription factor 3
HGNC id	13909

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 1800 - 343 - 2002 11863363 - - - 300 - 61 - 2002 11863363 NM_021240 2 - 2200 NP_067063 - 472 - 2002 11863363

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain       Mus musculus   spinal cord         Mus musculus Fetal Reproductive male system testis       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal DNA binding (DM)
	a proline and serine-rich region
	a functional NLS (nuclear localization signal) within the DM domain

HOMOLOGY

interspecies	homolog to Drosophila double sex
	homolog to C.elegans Mab3
	ortholog to F.rubripes
	ortholog to T.nigroviridis Dmrt3

intraspecies

paralog to DMRT1 and DMRT2

Homologene

FAMILY

DMRT family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	implicated in sexual development, and also may be involved in development of non-gonadal tissues
	DMRT3, induced NEUROG2 expression in the dorsal telencephalon

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
	DMRTA2 upregulates DMRT3 expression and negatively regulates its own expression, which may stabilize the level of DMRTA2, and likely DMRTA2, together with DMRT3, regulate patterning of the cerebral cortex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     of the cis-regulatory element for DMRT3 in humans may cause impaired development of the forebrain and gait abnormalities, resulting in spastic Cerebral palsy (CP)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS