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FLASH GENE
Symbol BDP1 contributors: mct/npt - updated : 04-04-2023
HGNC name B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
HGNC id 13652
PROTEIN
PHYSICAL PROPERTIES globular Hydrophilic
STRUCTURE
motifs/domains
  • nine repeats of a 55 aa motif rich in serine, lysine, glutamic acid (coded by exon 17)
  • a bipartite nuclear localization signal (NLS)
  • a DNA ligase A1 ATP-dependent binding site
  • essential region of BDP1 that is positioned within the active site cleft of Pol III and necessary for transcription initiation
  • a second NLS in the C terminal region
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae TFC7
    homolog to murine Bdp1 (53 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • acting as a transcription factor-like nuclear regulator
  • required for transcription from the Ad2 VAI and human U6RNA polymerase III promotors
  • transcription factor BDP1 is crucial to Pol III recruitment and promoter opening in transcription initiation
    • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the U6 initiation complex
  • subunit of the TFIIIB transcription initiation complex
  • three components (TBP, BRF1, and BDP1) in TFIIIB participate in crucial molecular events that include RNA polymerase recruitment, formation of the open initiation complex, and recycling of transcription
    • INTERACTION
    DNA
  • binding
    • RNA
    small molecule
    protein
  • ZBTB43
  • regulation of BDP1 occurs through JNK-mediated alterations in TBP expression
  • role of BDP1 in TFIIIB assembly and pre-initiation complex formation
    • cell & other
    REGULATION
    Other phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB112
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is disadvantageous and unfavorable for progression-free survival in serous ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BDP1 could likely be of clinical relevance as a predictive biomarker in serous ovarian cancer
    • Therapy target
    ANIMAL & CELL MODELS