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FLASH GENE
Symbol SLC22A7 contributors: mct/pgu - updated : 02-02-2021
HGNC name solute carrier family 22 (organic anion transporter), member 7
HGNC id 10971
Location 6p21.1      Physical location : 43.265.997 - 43.273.275
Synonym name
  • organic anion transporter 2
  • liver-specific transporter
  • novel liver transporter
  • organic anion transporter 11
    • Synonym symbol(s) OAT2, NLT, MGC45202, MGC24091, hOAT11
    DNA
    TYPE functioning gene
    STRUCTURE 7.28 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D6S273 - SLC22A7 - D6S271 - D6S459 - D6S452 - D6S436 - D6S466 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2559 - 548 - 2008 18216183
    10 - 2553 - 546 - 2008 18216183
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Urinarykidneytubule    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains (12TM)
  • cytoplasmic N and C termini
  • one nucleotide (ATP/GTP) binding site motif
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • SLC22 family of transport proteins
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • liver specific transport protein
  • play crucial roles in the renal secretion of various drugs
  • facilitative transporter for cGMP and other guanine nucleotides
  • may be involved in the regulation of cellular metabolism through the transport of short chain fatty acid propionate in the kidneys and the liver
  • operates as glutamate efflux transporter, and catalyses uptake of orotic acid
  • SLC22A7 is a likely relevant creatinine transporter and further challenging the traditional view that creatinine is solely transported by a cationic pathway
  • important role of SLC22A7 in renal secretion and possible reabsorption of creatinine
  • is emerging as an important drug transporter because of its expression in both the liver and kidney, two major eliminating organs, and its ability to transport not only a wide variety of xenobiotics but also numerous physiologically important endogenous compounds
  • marked interindividual variability likely in the hepatic expression of SLC22A7/SLC22A9, which may contribute to the pharmacokinetic variability of their substrates
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of SLC22A7 and sodium taurocholate cotransporting polypeptide (SLC10A1) with antineoplastic drugs
  • specific transport mechanism for Nicotinic acid (NA) uptake in the liver, suggesting that SLC22A7 has a critical role in its physiological and pharmacological functions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS