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FLASH GENE
Symbol ADAMTS8 contributors: npt/ - updated : 10-04-2006
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 8
HGNC id 224
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a prodomain
  • a Zn-binding site containing a disintegrin-like domain
  • two C terminal TS1 motifs
    • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • implicated in the mechanism of neovascularisation
  • may be involved in cell migration in the retina
    • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text disruption of angiogenesis negative control of proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS