Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ADAMTS8 contributors: npt/ - updated : 10-04-2006
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 8
HGNC id 224
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemprostate   
Respiratorylung    
Visualeyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a prodomain
  • a Zn-binding site containing a disintegrin-like domain
  • two C terminal TS1 motifs
    • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • implicated in the mechanism of neovascularisation
  • may be involved in cell migration in the retina
    • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text disruption of angiogenesis negative control of proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS