Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ADAMTS8

contributors: npt/ - updated : 10-04-2006

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 8
HGNC id	224

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	23.72 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ADAMTS8 9 - 3679 96.3 889 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary         male system prostate       Respiratory lung         Visual eye retina

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a prodomain
	a Zn-binding site containing a disintegrin-like domain
	two C terminal TS1 motifs

conjugated

MetalloP

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	implicated in the mechanism of neovascularisation
	may be involved in cell migration in the retina

CELLULAR PROCESS	cell life, proliferation/growth
	protein, degradation
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	disruption of angiogenesis negative control of proliferation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS