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FLASH GENE

Symbol

SCN3B

contributors: mct - updated : 15-09-2010

HGNC name	sodium channel, voltage-gated, type III, beta
HGNC id	20665

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BRGS7 , ATFB12

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in human cancer cell lines by DNA damaging agents, as well as by overexpression of Tp53 constitutional     --other   altered expression might influence microcircuitry in the hippocampus, affecting excitability and contributing to epileptogenesis in non-hippocampal sclerosis patients (van Gassen 2009)

Susceptibility

to atrial fibrillation

Variant & Polymorphism other	A130V mutant SCN3B negated the function of wild type SCN3B, suggesting that A130V acts by a dominant negative mechanism in atrial fibrillation

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Scn3b(-/-) hearts demonstrated significantly longer sinus node recovery times than WT hearts (Hakim 2009)