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FLASH GENE
Symbol SPDEF contributors: mct/npt/pgu - updated : 01-12-2015
HGNC name SAM pointed domain containing ets transcription factor
HGNC id 17257
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate cancer and in metastatic breast cancer in axillary lymph node
tumoral     --low  
leads to a morphologic change, increased migration and invasiveness in prostate cancer cells, reminiscent of transforming growth factor beta (TGFbeta) function and epithelial-to-mesenchymal transition
tumoral     --over  
prostate tumor cells where it regulates prostate-specific antigen gene expression and is an androgen receptor co-regulator
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • up-regulation is associated with a favorable prognosis in patients with clinically localized prostate cancer
  • Therapy target
    SystemTypeDisorderPubmed
    neurosensorialear 
    ATOH1 and SPDEF could be the therapeutic targets for otitis media associated with mucous cell metaplasia which is frequently considered "intractable" in the clinical settings
    ANIMAL & CELL MODELS