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FLASH GENE
Symbol SPDEF contributors: mct/npt/pgu - updated : 01-12-2015
HGNC name SAM pointed domain containing ets transcription factor
HGNC id 17257
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiens
 stomach     Homo sapiens
Reproductivefemale systemovary  highly Homo sapiens
 female systembreastmammary gland   Homo sapiens
 male systemprostate  highly Homo sapiens
Respiratoryrespiratory tract   moderately Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Digestivegoblet Homo sapiens
Reproductiveepithelial cell Homo sapiens
Respiratoryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two putative PEST sequences : one near the N terminus and the other at the center of the protein
  • a central pointed domain, which is characteristic of some ETS family members
  • an ETS DNA-binding domain
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Spdef (88.3pc)
    Homologene
    FAMILY
  • ETS (epithelial-specific E26 transforming sequence) family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • androgen independent transcriptional activator of the PSA promoter
  • regulator of prostate gland or prostate cancer development
  • acting as a transcriptional activator for SERPINB5 promoter
  • critical regulator of genes involved in cell motility, invasion, and adhesion of prostate cancer cells
  • in multiple invasive breast cancer cells, its expression inhibits cell migration by preventing the acquisition of directional morphological polarity conferred by changes in cytoskeleton organization
  • regulates goblet cell hyperplasia in the airway epithelium
  • important role in regulating intestinal epithelial cell homeostasis and differentiation, and regulates terminal differentiation and maturation of intestinal goblet cells
  • is potentially a negative regulator of tumor progression by modulating the expression of growth and migration promoting genes
  • required for mucous gland cell function in the gastric antrum
  • plays a critical role in regulating a transcriptional network mediating IL13-induced MUC5AC synthesis dependent on STAT6
  • negative regulator of tumor progression and metastasis
  • plays a significant role in tumorigenesis in prostate, breast, colon, and ovarian cancer, and functions as a tumor metastasis suppressor
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to 5'-GGAT- 3' DNA sequences
    RNA
    small molecule
    protein
  • the DNA-binding domain of the androgen receptor
  • NKX3-1
  • STMN1 is downregulated by PDEF, suggesting that PDEF may inhibit prostate cancer progression by transcriptional downregulation of oncogenic STMN expression
  • involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway
  • GADD45A and GADD45G, directly interact with CDK11A and thereby inhibit CDK11A activity, and consequentially SPDEF phosphorylation and degradation, ultimately reducing prostate cancer cell migration and invasion
  • cell & other
    REGULATION
    induced by by interleukin (IL13)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer and in metastatic breast cancer in axillary lymph node
    tumoral     --low  
    leads to a morphologic change, increased migration and invasiveness in prostate cancer cells, reminiscent of transforming growth factor beta (TGFbeta) function and epithelial-to-mesenchymal transition
    tumoral     --over  
    prostate tumor cells where it regulates prostate-specific antigen gene expression and is an androgen receptor co-regulator
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • up-regulation is associated with a favorable prognosis in patients with clinically localized prostate cancer
  • Therapy target
    SystemTypeDisorderPubmed
    neurosensorialear 
    ATOH1 and SPDEF could be the therapeutic targets for otitis media associated with mucous cell metaplasia which is frequently considered "intractable" in the clinical settings
    ANIMAL & CELL MODELS