basic FUNCTION
| androgen independent transcriptional activator of the PSA promoter |
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regulator of prostate gland or prostate cancer development |
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acting as a transcriptional activator for SERPINB5 promoter |
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critical regulator of genes involved in cell motility, invasion, and adhesion of prostate cancer cells |
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in multiple invasive breast cancer cells, its expression inhibits cell migration by preventing the acquisition of directional morphological polarity conferred by changes in cytoskeleton organization |
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regulates goblet cell hyperplasia in the airway epithelium |
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important role in regulating intestinal epithelial cell homeostasis and differentiation, and regulates terminal differentiation and maturation of intestinal goblet cells |
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is potentially a negative regulator of tumor progression by modulating the expression of growth and migration promoting genes |
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required for mucous gland cell function in the gastric antrum |
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plays a critical role in regulating a transcriptional network mediating IL13-induced MUC5AC synthesis dependent on STAT6 |
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negative regulator of tumor progression and metastasis |
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plays a significant role in tumorigenesis in prostate, breast, colon, and ovarian cancer, and functions as a tumor metastasis suppressor |