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FLASH GENE

Symbol

CDC42EP1

contributors: - updated : 17-09-2004

HGNC name	CDC42 effector protein (Rho GTPase binding) 1
HGNC id	17014

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.1      Physical location : 37.956.470 - 37.965.408
Synonym name	serum constituent protein,marrow stromal/endothelial cell protein
Synonym symbol(s)	CEP1, BORG5, MSE55

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 2140 40.3 391 - Bahou lacking a signal peptide containing a serie of 8 proline/alanine repeats as well as EF-hand motif variant 2 - splicing 2130 - 384 - Strausberg

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas       highly Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial barrier/lining       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage
cell lines
fluid/secretion	serum

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one CRIB domain (Cdc42/Rac interactive-binding)

HOMOLOGY

interspecies	homolog to murine Borg5-pending
	homolog to Drosophila mrg15
	homolog to C.elegans B0205.3

Homologene

FAMILY

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	extracellular
text	secreted

basic FUNCTION	hematopoiesis
	promotes the attachment of developing bone marrow granulocytic cells to bone marrow stroma
	mediates actin cytoskeleton reorganization at the plasma membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

binding to CDC42

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS