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FLASH GENE
Symbol CDC42EP1 contributors: - updated : 17-09-2004
HGNC name CDC42 effector protein (Rho GTPase binding) 1
HGNC id 17014
Location 22q13.1      Physical location : 37.956.470 - 37.965.408
Synonym name serum constituent protein,marrow stromal/endothelial cell protein
Synonym symbol(s) CEP1, BORG5, MSE55
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2140 40.3 391 - Bahou
  • lacking a signal peptide
  • containing a serie of 8 proline/alanine repeats as well as EF-hand motif
  • - splicing 2130 - 384 - Strausberg
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier/lining   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one CRIB domain (Cdc42/Rac interactive-binding)
    HOMOLOGY
    interspecies homolog to murine Borg5-pending
    homolog to Drosophila mrg15
    homolog to C.elegans B0205.3
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • hematopoiesis
  • promotes the attachment of developing bone marrow granulocytic cells to bone marrow stroma
  • mediates actin cytoskeleton reorganization at the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein binding to CDC42
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS