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FLASH GENE

Symbol

MAP2K2

contributors: npt/mct/pgu - updated : 14-09-2013

HGNC name	mitogen-activated protein kinase kinase 2
HGNC id	6842

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CFC4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       missense mutation in CFC tumoral somatic mutation       in melanomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Mek2-deficient mice were viable and fertile and showed no phenotypic abnormalities. Mutant embryonic fibroblasts and purified lymphocytes proliferated normally, demonstrating that Mek2 is not required for reentry into the cell cycle or for T-cell development concluding that MEK1 can compensate for a lack of MEK2 function