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FLASH GENE

Symbol

LMO4

contributors: mlct/npt - updated : 23-12-2015

HGNC name	LIM domain only 4
HGNC id	6644

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea   highly Reproductive female system breast       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Epithelial absorptive excretory alveolar epithelium     Epithelial secretory glandular     Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	cranial neural crest, somites

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two N terminal cysteine-rich LIM/double zinc finger motifs (LIM domains)

HOMOLOGY

interspecies

homolog to murine Lmo4

intraspecies

homolog to LMO1

Homologene

FAMILY	LIM domain containing transcription factor
	LMO subfamily

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	transcriptional regulator participating to mammary gland development
	repressor of BRCA1 in breast tissue
	GRHL3 and LMO4 play coordinate roles in epidermal migration
	novel cell cycle regulator with a key role in mediating ERBB2-induced proliferation, a hallmark of ERBB2-positive cancer
	has similar cellular effects in normal mammary epithelial cells and breast cancer cells, and also provide direct evidence for the idea that normal development and carcinogenesis share conserved molecular mechanisms
	transcription cofactor expressed during retinal development and in amacrine neurons at birth
	essential postnatal function of LMO4 in the differentiation of BHLHB5-expressing inhibitory interneurons in the retina
	promotes the acquisition of cortical neuronal identities by forming a complex with NEUROG2 and subsequently activating NEUROG2-dependent gene expression

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	LDBS
	DEAF1
	RBBP8 and BRCA1 and inhibiting BRCA1 activity
	interacted strongly to LDB1, which was required for the localization to the nucleus
	LMO4 serves as a functional partner of GRHL3
	role for transcription factor LMO4 in thymus development through genetic interaction with CITED2
	functions as a novel co-factor of NEUROG2 in the developing cortex
	overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of RBBP8, thereby contributing to breast cancer progression
	LDB1 in a complex with LMO4, supports mammary stem cells by directly targeting the FGFR2 promoter in basal cells to increase its expression
	SSBP2, SSBP3 control LMO4 and LDB1 protein abundance in a cancer context

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer cell lines tumoral   amplification     in squamous cell carcinoma of the oral cavity tumoral     --over   inducing mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer tumoral     --over   in late stage pancreas cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS