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FLASH GENE
Symbol AUH contributors: - updated : 12-02-2007
HGNC name AU RNA binding protein/enoyl-Coenzyme A hydratase
HGNC id 890
Corresponding disease
MTGA1 3-methylglutaconicaciduria type I
Location 9q22      Physical location : 93.976.098 - 94.124.206
Synonym name
  • AU-binding protein/enoyl-CoA hydratase
  • methylglutaconyl-CoA hydratase, mitochondrial
  • EC.number 4.2.1.18
    DNA
    TYPE functioning gene
    STRUCTURE 148.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see ROR2
    Physical map
    GADD45G 9q22.1-q22.2 growth arrest and DNA-damage-inducible, gamma LOC389770 9 similar to QCWQ6494 LOC389771 9 LOC389771 LOC157916 9q22.31 interleukin 6 receptor pseudogene LOC392365 9 similar to putative taste receptor HTR2 LOC392366 9 similar to seven transmembrane helix receptor DIRAS2 9q22.32 DIRAS family, GTP-binding RAS-like 2 LOC392367 9 similar to putative taste receptor HTR2 LOC283493 9q22.31 similar to seven transmembrane helix receptor SYK 9q22.1-q22.3 spleen tyrosine kinase AUH 9q22 AU RNA binding protein/enoyl-Coenzyme A hydratase NFIL3 9q22 nuclear factor, interleukin 3 regulated ROR2 9q22.3 receptor tyrosine kinase-like orphan receptor 2 LOC347318 9q22.31 similar to 60S ribosomal protein L21 SPTLC1 9q22.1-q22.2 serine palmitoyltransferase, long chain base subunit 1 LOC389772 9 similar to Osteotesticular phosphatase; protein tyrosine phosphatase, receptor type, V LOC392368 9 similar to KIAA1553 protein LOC138652 9q22.32 similar to bA62C3.1 (similar to testicular serine protease) IARS 9q21 isoleucine-tRNA synthetase C9orf34 9q22.32 chromosome 9 open reading frame 34 OGN 9q22.3 osteoglycin (osteoinductive factor, mimecan) OMD 9p22.3 osteomodulin ASPN 9q22-q31 asporin (LRR class 1) ECM2 9q22.3 extracellular matrix protein 2, female organ and adipocyte specific C9orf12 9q21.33-q22.31 chromosome 9 open reading frame 12 BICD2 9q22.1-q22.3 chromosome 9 open reading frame 12 ANKRD19 9q22.32 ankyrin repeat domain 19 BA526D8.4 9q22.32 KRAB box containing C2H2 type zinc finger bA526D8.4 LOC389773 9 LOC389773 LOC340518 9q22.32 similar to Alox15 protein
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbraindiencephalonhypothalamus  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    separate domains for RNA binding and hydratase activity
    mono polymer homomer , hexamer
    isoforms Precursor 40-kDa precursor protein
    HOMOLOGY
    interspecies ortholog to murine Auh
    Homologene
    FAMILY enoyl-CoA hydratase/isomerase family
    CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • bifunctional enzyme with both RNA-binding and enoyl-CoA-hydratase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    text elimination of short life RNAs
    PATHWAY
    metabolism aminoacid
    signaling
    leucine degradation
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTGA1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS