basic FUNCTION
| TP53-regulated gene, involved in growth arrest, cell differentiation and playing a growth inhibitory role |
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playing mainly a crucial function in the development and/or maintenance of peripheral nerves |
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mast cell maturation-associated inducible protein that allows the cells to be susceptible to extracellular stimuli leading to degranulation |
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playing a necessary but not sufficient role for TP53-mediated caspase activation and apoptosis |
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playing a putative role in the general mechanisms of HDL-mediated cholesterol transport |
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involbed in stress responses, hormone responses, cell growth, and differentiation |
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intracellular protein associated with stress response, cell growth, and differentiation |
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may play a partially redundant role in specific cells in the brain |
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nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis, most likely through its ability to induce cellular differentiation |
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may play an inhibitory role during the development of glioma and may be a potential prognosis predictor of glioma |
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importance of NDRG1 as a growth control gene in breast tissue |
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differentiation-related gene that plays important roles in cell differentiation, organ formation, and embryonic development |
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plays a significant role in invasion and metastasis of cancer |
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up-regulated CD82 expression through modulation of ATF3 signaling in prostate cancer cells |
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involved in tumor adaptation to reoxygenation |
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is an iron-regulated metastasis suppressor which is up-regulated by iron depletion and may be involved in the epithelial-mesenchymal transition (EMT) |
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is involved in the EMT through the SMAD and Wnt pathways |
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SGK1 and NDRG1 participate in the regulation of NFKB1 signaling and maturation of dendritic cells (DCs) |