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FLASH GENE

Symbol

KPNA4

contributors: mct - updated : 23-10-2018

HGNC name	karyopherin alpha 4 (importin alpha 3)
HGNC id	6397

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	70.59 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

repetitive sequence   ALU   long interspersed repetitive elements

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002268 17 - 8981 NP_002259 57.8 521 - Ewing (2007)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Endocrine pancreas         Lymphoid/Immune thymus         Reproductive female system breast mammary gland   highly   male system testis       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal importin beta-binding (IBB) domain
	eight armadillo repeats and nuclear localization signal (NLS)
	a C terminal acidic region

HOMOLOGY

interspecies

ortholog to murine Kpna4

intraspecies

homolog to KPNA2

Homologene

FAMILY

importin alpha protein family

CATEGORY

signaling , receptor nuclear

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nuclear envelope

basic FUNCTION	promoting docking of import substrates to the nuclear pore complex
	mediating nuclear import of DHX9 through importin-alpha3/importin-beta-dependent pathway
	KPNA4 is an HIV integrase-interacting cofactor that is required for efficient HIV-1 nuclear import and replication in both dividing and nondividing cells
	unconventional nuclear localization signals (NLS) within nucleoprotein (NP) might have the additional ability to regulate the viral replication that is independent of nuclear localization activity via interactions with KPNA4

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

signal transduction

a component

component of the NLS import receptor including an heterodimer of importin alpha and beta

INTERACTION

DNA

RNA

small molecule

protein	binding the nuclear localization signal NLS of nuclear proteins
	interacting with DHX9 (basic residues in RHA-NLS were used for interaction with importin-alpha)
	nuclear localization of DAXX is controlled by two independent signals and KPNA4 through its NLS1 and NLS2 sequences
	stress-induced accumulation of non-ubiquitinated TP53 in the cytoplasm promotes interaction with KCNA4 and rapid import
	KPNA3 and KPNA4 are key binding partners of MECP2, and mediate the nuclear import of MECP2
	KPNA4 mediates the cytoplasm-to-nucleus translocation of transcription factors, including nuclear factor kappa B
	KPNA4 is an important regulator of CNTF-induced oligodendrocyte differentiation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	KPNA4 is a potential novel biomarker for Prostate carcinoma metastasis
Therapy target

ANIMAL & CELL MODELS