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FLASH GENE
Symbol KPNA4 contributors: mct - updated : 23-10-2018
HGNC name karyopherin alpha 4 (importin alpha 3)
HGNC id 6397
Location 3q25.33      Physical location : 160.217.962 - 160.283.376
Synonym name
  • importin alpha 3
  • importin-alpha-Q1
  • Qip1 protein
  • importin subunit alpha-3
  • Synonym symbol(s) QIP1, SRP3, IMA4, IPOA3, MGC12217, MGC26703
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 70.59 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU   long interspersed repetitive elements
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 8981 57.8 521 - Ewing (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Lymphoid/Immunethymus    
    Reproductivefemale systembreastmammary gland highly
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal importin beta-binding (IBB) domain
  • eight armadillo repeats and nuclear localization signal (NLS)
  • a C terminal acidic region
  • HOMOLOGY
    interspecies ortholog to murine Kpna4
    intraspecies homolog to KPNA2
    Homologene
    FAMILY importin alpha protein family
    CATEGORY signaling , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    basic FUNCTION
  • promoting docking of import substrates to the nuclear pore complex
  • mediating nuclear import of DHX9 through importin-alpha3/importin-beta-dependent pathway
  • KPNA4 is an HIV integrase-interacting cofactor that is required for efficient HIV-1 nuclear import and replication in both dividing and nondividing cells
  • unconventional nuclear localization signals (NLS) within nucleoprotein (NP) might have the additional ability to regulate the viral replication that is independent of nuclear localization activity via interactions with KPNA4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the nuclear localization signal NLS of nuclear proteins
  • interacting with DHX9 (basic residues in RHA-NLS were used for interaction with importin-alpha)
  • nuclear localization of DAXX is controlled by two independent signals and KPNA4 through its NLS1 and NLS2 sequences
  • stress-induced accumulation of non-ubiquitinated TP53 in the cytoplasm promotes interaction with KCNA4 and rapid import
  • KPNA3 and KPNA4 are key binding partners of MECP2, and mediate the nuclear import of MECP2
  • KPNA4 mediates the cytoplasm-to-nucleus translocation of transcription factors, including nuclear factor kappa B
  • KPNA4 is an important regulator of CNTF-induced oligodendrocyte differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KPNA4 is a potential novel biomarker for Prostate carcinoma metastasis
  • Therapy target
    ANIMAL & CELL MODELS