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FLASH GENE
Symbol SLC4A10 contributors: KTN/npt - updated : 18/11/2008
HGNC name solute carrier family 4, sodium bicarbonate transporter-like, member 10
HGNC id 13811
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane regions
    • HOMOLOGY
    interspecies homolog to dog SLC4A10 (99.3 pc)
    homolog to chimpanzee SLC4A10 (99.7 pc)
    homolog to cow SLC4A10 (99.3 pc)
    homolog to rattus Slc4a10 (97.4 pc)
    homolog to murine Slc4a10 (97.3 pc)
    Homologene
    FAMILY
  • anion exchanger family
    • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
  • localized to the basolateral membrane
    • basic FUNCTION
  • acting as an electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride
  • playing an important role in regulating intracellular pH
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text symport and antiport of ions (Na+, Cl- and HCO3-)
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    t(2;13)(q24;q31) in epilepsy and cognitive impairment
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism other de novo copy number variant in autism spectrum disorder
    Candidate gene
    Marker
    Therapy target
  • being a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.
    • ANIMAL & CELL MODELS
    Slc4a10 -/- mice (Jacobs, 2008)