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FLASH GENE
Symbol SLC4A10 contributors: KTN/npt - updated : 18/11/2008
HGNC name solute carrier family 4, sodium bicarbonate transporter-like, member 10
HGNC id 13811
Location 2q24.2      Physical location : 162.480.844 - 162.841.785
Synonym name solute carrier family 4 member 10
Synonym symbol(s) NCBE, NBCn2
DNA
TYPE functioning gene
STRUCTURE 360.94 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU   long interspersed repetitive elements
MAPPING cloned Y linked N status confirmed
Map cen - D2S2754 - SLC4A10 - D2S2553 - qter
Authors Yano (00)
Physical map
OR7E89P 2q31.3 olfactory receptor, family 7, subfamily E, member 89 pseudogene LOC391457 2 similar to putative taste receptor HTR2 OR7E90P 2q31.3 olfactory receptor, family 7, subfamily E, member 90 pseudogene MGC23908 2 similar to RNA polymerase B transcription factor 3 KIAA1728 2q24.2 KIAA1728 protein FLJ36175 2q24.2 hypothetical protein FLJ36175 BAZ2B 2q23-q24 bromodomain adjacent to zinc finger domain, 2B AXOT 2q24.2 axotrophin DCL-1 2q24.2 type I transmembrane C-type lectin receptor DCL-1 LY75 2p24 lymphocyte antigen 75 PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1 TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha MDA5 2p24.3-q24.3 melanoma differentiation associated protein-5 GCA 2q24.3 grancalcin, EF-hand calcium binding protein KCNH7 2q24.3 potassium voltage-gated channel, subfamily H (eag-related), member 7 FIGN 2q24.2 fidgetin
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 5580 122.5 1088 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestineileum  
Endocrinepancreas   highly
Lymphoid/Immunelymph node   moderately
Nervousbrain   predominantly
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane regions
  • HOMOLOGY
    interspecies homolog to dog SLC4A10 (99.3 pc)
    homolog to chimpanzee SLC4A10 (99.7 pc)
    homolog to cow SLC4A10 (99.3 pc)
    homolog to rattus Slc4a10 (97.4 pc)
    homolog to murine Slc4a10 (97.3 pc)
    Homologene
    FAMILY
  • anion exchanger family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
  • localized to the basolateral membrane
  • basic FUNCTION
  • acting as an electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride
  • playing an important role in regulating intracellular pH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text symport and antiport of ions (Na+, Cl- and HCO3-)
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    t(2;13)(q24;q31) in epilepsy and cognitive impairment
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism other de novo copy number variant in autism spectrum disorder
    Candidate gene
    Marker
    Therapy target
  • being a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.
  • ANIMAL & CELL MODELS
    Slc4a10 -/- mice (Jacobs, 2008)