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FLASH GENE

Symbol

EI24

contributors: mct - updated : 27-05-2014

HGNC name	etoposide induced 2.4 mRNA
HGNC id	13276

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q24.2      Physical location : 125.439.297 - 125.454.574
Synonym name	tumor protein p53 inducible protein 8
Synonym symbol(s)	PIG8, TP53I8, EPG4

DNA

TYPE	functioning gene
STRUCTURE	15.28 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
motif	repetitive sequence   ALU   long interspersed repetitive elements
text structure	promoter was activated by E2F1 via multiple E2F-responsive elements, independently of the previously reported TP53-responsive element (

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004879 11 - 2279 NP_004870 38 340 - 2013 24280371 isoform 1 NM_001007277 10 - 2167 NP_001277064 29 262 - 2013 24280371 lacking a coding exon as compared to variant 1, resulting in a frameshift and an early transcription termination isoform 2

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six transmembrane domains

HOMOLOGY

interspecies	homolog to murine Ei24 (98.2pc)
	homolog to rattus Ei24 (98.2pc)

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
	intracellular,nuclear envelope
text	BCL2-binding protein localized on the endoplasmic reticulum with potential roles in preventing the spreading of tumors

basic FUNCTION	playing an important role in negative cell growth control by functioning as an apoptotic effector of p53 tumor suppressor activities
	proapoptotic activity that is involved in sensitivity to chemotherapy
	DNA damage response gene involved in growth suppression and apoptosis
	is an essential autophagy gene and plays an important role in clearance of aggregate-prone proteins in neurons and hepatocytes
	potentially a new prognostic marker of chemotherapy responsiveness
	is a novel E2F target gene contributing to the survival of TP53-deficient cells upon UVC irradiation
	may act as a key mediator in the downstream pathways of both RB1/E2F and TP53
	critical mediator/effector required for the crosstalk between TP53 and RB1/E2F pathways dedicated to tumor suppression
	has a multifaceted role against tumor progression that is regulated by both EMT and inflammation
	is a critical suppressor of tumor progression

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

EI24 can bind specifically to KPNA2/KPNB1 to impede their normal role in nuclear import, shedding new light on the cellular functions of EI24 and its tumor suppressor role

cell & other

REGULATION

induced by

TP53

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in breast cancers tumoral       loss of function contributes significantly to resistance of cells to chemotherapeutic agents that function through TP53

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     useful therapeutic and diagnostic marker cancer     potential significance as a therapeutic target of certain chemotherapy for treating TP53-deficient tumors

ANIMAL & CELL MODELS