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FLASH GENE
Symbol ANKRA2 contributors: mct - updated : 03-12-2011
HGNC name ankyrin repeat, family A (RFXANK-like), 2
HGNC id 13208
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three ankyrin repeats domains
    • HOMOLOGY
    interspecies homolog to murine Ankra2 (95.2pc)
    intraspecies paralog to RFXANK
    Homologene
    FAMILY
    CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • colocalizing with megalin
  • enriched in apical membranes of the proximal tubule
    • basic FUNCTION
  • playing a role in megalin's function
  • may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery
  • playing a potential role as mediator in transcriptional repression
  • could modulate the excitability of neurons by binding directly to endogenous BKCa channel and altering its gating kinetics in a calcium-dependent manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • megalin tail binding
  • may interact with histone deacetylases
  • interacting with AHRR and with HDAC4, HDAC5
  • corepressor for AHRR
  • megalin- and BKCa potassium channel-interacting factor
  • HDAC4 and HDAC5 interact with the ankyrin repeats of ANKRA2 and RFXANK and, through association with RFXANK, repress MHC II promoter activation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS