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FLASH GENE

Symbol

ANKRA2

contributors: mct - updated : 03-12-2011

HGNC name	ankyrin repeat, family A (RFXANK-like), 2
HGNC id	13208

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q13.2      Physical location : 72.848.024 - 72.861.511
Synonym symbol(s)	RFXANKL2, ANKRA

DNA

TYPE	functioning gene
STRUCTURE	13.49 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

repetitive sequence   ALU   long interspersed repetitive elements

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_023039 9 - 2198 - 313 - 2000 11095640

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex     Urinary kidney nephron renal capsule glomerulus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Urinary epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three ankyrin repeats domains

HOMOLOGY

interspecies

homolog to murine Ankra2 (95.2pc)

intraspecies

paralog to RFXANK

Homologene

FAMILY

CATEGORY

regulatory , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	colocalizing with megalin
	enriched in apical membranes of the proximal tubule

basic FUNCTION	playing a role in megalin's function
	may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery
	playing a potential role as mediator in transcriptional repression
	could modulate the excitability of neurons by binding directly to endogenous BKCa channel and altering its gating kinetics in a calcium-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	megalin tail binding
	may interact with histone deacetylases
	interacting with AHRR and with HDAC4, HDAC5
	corepressor for AHRR
	megalin- and BKCa potassium channel-interacting factor
	HDAC4 and HDAC5 interact with the ankyrin repeats of ANKRA2 and RFXANK and, through association with RFXANK, repress MHC II promoter activation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS