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FLASH GENE

Symbol

CDK5R2

contributors: npt/mct - updated : 24-06-2016

HGNC name	cyclin-dependent kinase 5, regulatory subunit 2 (p39)
HGNC id	1776

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.48 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence   ALU   long interspersed repetitive elements
text structure	intronless

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CDK5R2 1 - 2495 38 367 - Hillier (2005)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland           pancreas         Nervous brain         Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal p10 regions
	C-terminal CDK5 activation domains (AD)

mono polymer

heteromer , dimer

HOMOLOGY

intraspecies

paralog to CDK5R1

Homologene

FAMILY

cyclin-dependent kinase 5 activator family

CATEGORY

enzyme , regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

neuronal activator of CDK5

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimerizing with CDK5

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

cleaved to p29 by Ca2+ calpain

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS