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FLASH GENE
Symbol CDK5R2 contributors: npt/mct - updated : 24-06-2016
HGNC name cyclin-dependent kinase 5, regulatory subunit 2 (p39)
HGNC id 1776
Location 2q35      Physical location : 219.824.397 - 219.826.876
Synonym name
  • neuronal CDK5 activator isoform
  • CDK5 activator 2
    • Synonym symbol(s) P39, NCK5AI, p39nck5ai, P39I
    DNA
    TYPE functioning gene
    STRUCTURE 2.48 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU   long interspersed repetitive elements
    text structure intronless
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2495 38 367 - Hillier (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     pancreas    
    Nervousbrain    
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal p10 regions
  • C-terminal CDK5 activation domains (AD)
    • mono polymer heteromer , dimer
    HOMOLOGY
    intraspecies paralog to CDK5R1
    Homologene
    FAMILY
  • cyclin-dependent kinase 5 activator family
    • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • neuronal activator of CDK5
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with CDK5
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cleaved to p29 by Ca2+ calpain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS