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FLASH GENE
Symbol TSFM contributors: - updated : 11-10-2006
HGNC name Ts translation elongation factor, mitochondrial
HGNC id 12367
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
 pharynx   highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal mitochondrial signal peptide
HOMOLOGY
interspecies homolog to bovine EF-TSMT
homolog to Drosophila CG6412
homolog to C.elegans F55C5.5
Homologene
FAMILY EF-TS family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • inducing the exchange of GDP to GTP
  • guanine nucleotide exchange factor that binds to the TUFM
    • guanosine diphosphate (GDP) complex, promoting the release of GDP and the formation of a stable TUFM
    TSFM heterodimer
    CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associated with the TUFM.GDP complex
    INTERACTION
    DNA
    RNA binding to aminoacyl-tRNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS