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FLASH GENE
Symbol SCT contributors: - updated : 18-02-2006
HGNC name secretin
HGNC id 10607
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveintestinesmall intestineduodenum lowly
 intestinesmall intestinejejunum lowly
Nervousbrain   lowly
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • prosecretin made of a signal peptide
  • the bioactive mature secretin
  • a C terminal tail
    • HOMOLOGY
    interspecies homolog to murine Sct
    Homologene
    FAMILY glucagon family
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • stimulating the secretion of bicarbonate-rich pancreatic fluids and inhibiting HCL production by the stomac
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by the Sp1/Sp3 ratio and the methylation status of the promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autistic disorders
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS