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FLASH GENE

Symbol

SCT

contributors: - updated : 18-02-2006

HGNC name	secretin
HGNC id	10607

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	0.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (TATA box)
	cytosine-phosphate-guanine/HTF
	Binding site
motif	repetitive sequence
text structure	binding sites for SP-1, SP-3, AP-4 transcription factors
	VWTR proximal to the promoter region
	functional motifs including an E-box and 2 GC-boxes

MAPPING

cloned

Y

linked

N

status

provisional

Map

see INS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive intestine small intestine duodenum   lowly   intestine small intestine jejunum   lowly Nervous brain       lowly Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	prosecretin made of a signal peptide
	the bioactive mature secretin
	a C terminal tail

HOMOLOGY

interspecies

homolog to murine Sct

Homologene

FAMILY

glucagon family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

stimulating the secretion of bicarbonate-rich pancreatic fluids and inhibiting HCL production by the stomac

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by the Sp1/Sp3 ratio and the methylation status of the promoter

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to autistic disorders

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS