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FLASH GENE

Symbol

BZW1

contributors: mct/npt - updated : 03/10/2008

HGNC name	basic leucine zipper and W2 domains 1
HGNC id	18380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q33      Physical location : 201.676.646 - 201.688.559
Synonym name	KIAA0005 gene product
	basic leucine zipper and W2 domain-containing protein 1
	protein Orf
Synonym symbol(s)	KIAA0005, BZAP45, Nbla10236

DNA

TYPE	functioning gene
STRUCTURE	11.91 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed BZW1 12 - 2816 - 353 - Olsen (2006)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver       highly Endocrine pancreas         Nervous brain       highly Reproductive male system prostate     highly Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a eIF4-gamma/eIF5/eIF2-epsilon domain
	ATP/GTP binding motif A (P-loop)

HOMOLOGY

interspecies

homolog to murine Bzw1

Homologene

FAMILY

BZW family

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	contributing to transcriptional control at the G1/S phase transition
	regulating translational initiation
	conserved regulatory factor for transcriptional control of histone H4 gene at the G1/S transition

CELLULAR PROCESS	nucleotide, transcription, regulation
	protein, translation regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule	nucleotide,
	ATP/GTP

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS