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FLASH GENE

Symbol

TRIM37

contributors: mct - updated : 13-04-2007

HGNC name	tripartite motif-containing 37
HGNC id	7523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RING finger
	a B box type 2 motif
	a coiled-coil domain
	a MATH (meprin and tumour-necrosis factor receptor-associated factor homology) domain
	a nuclear coil localization signal (NLS)
	two aspartate-glutamate serine (DES) rich sequence at the C terminus

HOMOLOGY

Homologene

FAMILY	tripartite motif (TRIM, RING-B-box-coiled-coil)-family
	C-VIII TRIM family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,peroxisome

basic FUNCTION	putatively involved in development and oncogenesis
	acting as a TRIM domain-dependent E3 ubiquitin ligase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by several mechanisms: through nonsense surveillance of non-functional transcripts, as well as through 3 prime UTR regulatory sequences and/or naturally occurring antisense RNAs especially in testis

ASSOCIATED DISORDERS

corresponding disease(s)

MUL

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS