Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TRIM37

contributors: mct - updated : 13-04-2007

HGNC name	tripartite motif-containing 37
HGNC id	7523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	124.00 kb     25 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - MTMR3 - SEPT4 - RAD51C - TRIM37 - qter
Authors	Avela (00)

regionally located

in the 17q23 amplicon, in breast cancer

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1, or TRIM37A - - 4488 - 964 expressed in testis, but is prominent in other tissues Hamalainen (2006) variant 2, or TRIM37B - - 3588 - 964 expressed in testis Hamalainen (2006) an alternative termination codon and 3'untranslated region (UTR) transcribed from an exon 16 kb downstream from exon 24

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive esophagus       highly Endocrine neuroendocrine pituitary     highly Nervous brain       highly Reproductive male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RING finger
	a B box type 2 motif
	a coiled-coil domain
	a MATH (meprin and tumour-necrosis factor receptor-associated factor homology) domain
	a nuclear coil localization signal (NLS)
	two aspartate-glutamate serine (DES) rich sequence at the C terminus

HOMOLOGY

Homologene

FAMILY	tripartite motif (TRIM, RING-B-box-coiled-coil)-family
	C-VIII TRIM family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,peroxisome

basic FUNCTION	putatively involved in development and oncogenesis
	acting as a TRIM domain-dependent E3 ubiquitin ligase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by several mechanisms: through nonsense surveillance of non-functional transcripts, as well as through 3 prime UTR regulatory sequences and/or naturally occurring antisense RNAs especially in testis

ASSOCIATED DISORDERS

corresponding disease(s)

MUL

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS