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FLASH GENE
Symbol MTBP contributors: shn - updated : 21-03-2012
HGNC name Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
HGNC id 7417
Location 8q24.12      Physical location : 121.457.665 - 121.535.875
Synonym name
  • Murine double minute 2 (MDM2) binding protein
  • MDM2 (mouse double minute 2)-binding protein, 104kD
  • mdm2-binding protein
  • Synonym symbol(s) MDM2BP, hMTBP, MTBP @ LOVD, MDM2BP
    DNA
    TYPE functioning gene
    STRUCTURE 78.21 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D8S269 - D8S586 - MTBP - D8S1112 - D8S1728 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3080 - 904 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  lowly Homo sapiens
    Lymphoid/Immunespleen   lowly Homo sapiens
     thymus   highly Homo sapiens
    Reproductivefemale systemovary  moderately Homo sapiens
     male systemtestis  highly Homo sapiens
     male systemprostate  lowly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Mtbp, Mus musculus
    ortholog to MTBP, Pan troglodytes
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text localized at the kinetochores during prometaphase (
    basic FUNCTION
  • putative growth regulator and tumor suppressor gene
  • promoting MDM2-mediated ubiquitination and degradation of TP53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner
  • differentially regulating the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and TP53) and in doing so significantly contributes to MDM2-dependent TP53 homeostasis in unstressed cells
  • a crucial role in proper mitotic progression and faithful chromosome segregation (
  • implicated in cancer progression
  • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text tumor cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MDM2 (
  • suppresses cell migration, at least partially, by inhibiting ACTN4 function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • a potential biomarker for cancer progression
  • Therapy target
    ANIMAL & CELL MODELS
  • MTBP downmodulation leads to an abbreviated metaphase and insufficient mitotic arrest, abnormal chromosome segregation, aneuploidy, decreased cell proliferation, senescence, and cell death (