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FLASH GENE
Symbol KPNA1 contributors: mct - updated : 17-06-2015
HGNC name karyopherin alpha 1 (importin alpha 5)
HGNC id 6394
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminus importin-beta binding domain
  • an arm repeats (8 repeats), homolog to the drosophila armadillo motif
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast SRP1,Xenopus importin
    Homologene
    FAMILY importin alpha protein family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text cytoplasmic face of the nuclear pore complex (NPL) translocated to nucleus after loading a nuclear protein and complexing with importin beta
    basic FUNCTION nuclear import of proteins
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the NLS import receptor including an heterodimer of importin alpha and beta
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the nuclear localization signal NLS of nuclear proteins
  • KPNA1 binds to Kir/GEM, and its depletion using RNA interference impairs nuclear translocation of this RGK protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS