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FLASH GENE

Symbol

KLK14

contributors: mct - updated : 22-04-2020

HGNC name	kallikrein-related peptidase 14
HGNC id	6362

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in testicular and ovarian cancer tumoral     --over   in invasive breast carcinomas compared to normal breast tissues, associated with higher tumour grade and size constitutional     --other   differentially expressed in asthenospermic cases tumoral     --over   during Prostate carcinoma development, and in advanced PCa, and particularly in metastasis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	its expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies
	may be a promising new biomarker in salivary gland tumors
	KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for Colon cancer (CC) patients with discriminating power between CC and adenoma patients
Therapy target	therapeutic induction of the seminal proteolytic cascade can be utilized to supplement the current clinical treatment of male subfertility and conversely, targeted inhibition of key components of the cascade may have potential pharmaceutical utility as a novel topical contraceptive strategy
	potential target for the treatment of skin disorders in which KLK activity is elevated

ANIMAL & CELL MODELS