Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

POLR3A

contributors: mct/shn - updated : 14-01-2019

HGNC name	polymerase (RNA) III (DNA directed) polypeptide A
HGNC id	30074

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007055 31 - 6610 NP_008986 155 1390 - 2018 30450527

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to Polr3a, Mus musculus
	ortholog to Polr3a, Rattus norvegicus
	ortholog to polr3a, Danio rerio
	ortholog to POLR3A, Pan troglodytes

Homologene

FAMILY

RNA polymerase beta chain family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
	has likely critical functions in human development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

plakophilin 2

cell & other

REGULATION

Other

regulated by DNMT1 and DNMT3a

ASSOCIATED DISORDERS

corresponding disease(s)

HLD7 , NPROS

Susceptibility

to severe Varicella zoster virus (VZV) disease

Variant & Polymorphism other	monogenic or digenic POLR3C deficiencies confer increased susceptibility to severe VZV disease in otherwise healthy children

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS